Human patients have benefited from cancer immunotherapy for around 20 years, but it is just now being adapted for veterinary use.

A team of researchers from Messerli Research Institute of the Vemeduni Vienna, the Medical University of Vienna, and the University of Vienna reported in Molecular Cancer Therapeutics that they have developed the first antibodies capable of targeting canine cancer.

According to the scientists, cancer immunotherapy has long been used in human medicine because of its effective approach leveraging antibodies that bind to cancer cells and inhibit tumor growth. The antibodies trigger the death of cancer cells and stimulate the patient's immune system to destroy targeted tumors.

In order to modify cancer immunotherapy for dogs, the researchers had to "trim" or "caninize" the antibody to specifically bind with receptors on dogs' cancer cells. This was relatively simple due to the fact that a receptor commonly found on human tumor cells - EGFR - is almost 100 percent identical to the corresponding receptor on dogs, researchers reported.

After trimming the antibody to target canine cancer cells, researchers "expect dogs to tolerate these anti-cancer antibodies well," said Erika Jensen-Jarolim, MD, chair for comparative medicine at the interdisciplinary Messerli Research Institute, in a Bioscience Technology article. 

The scientists pointed to an additional benefit of using cancer immunotherapy on dogs, which is the ability to pair antibodies with radioactive isotopes to enable the visual detection of tumors and metastases.

Though they still have more to learn about this potential cancer treatment, researchers said it so far appears to be safe and effective for use in dogs.

"In summary, this newly generated 'caninized' anti-EGFR antibody seems to be highly specific as well as effective in targeting EGFR-overexpressing canine tumor cells. Its caninization prevents adverse reactions, such as anaphylaxis or serum sickness in treated dogs, making this antibody a safe research lead compound for the first passive immunotherapy approaches in canine patients with cancer," researchers wrote in their published study.

Comments (1) -

Vadim Shapoval
Vadim ShapovalUkraine
7/22/2014 4:56:00 AM #

Canine cancer is a strange disease: cancerous cells are iron-overloaded (iron-rich, iron-saturated) cells. The immune system in a dog is made up of a collection of specialized cells, proteins, tissues, and organs. Unfortunately, the immune system in a dog cannot determine, fix, correct and repair iron-overloaded cells. The Father of Oncology (Vadim Shapoval) says that a cell needs to have iron overload (when excessive iron accumulates within cellular organelles) before it becomes cancerous. Canine cancer is caused by iron-related genes (numerous genes directly/indirectly involved in iron metabolism / hereditary cancers) and iron-related events (when excessive iron accumulates within the cells, tissues, and organs due to various carcinogenic lifestyle events / sporadic cancers). According to the Ferromagnetic Cancer Theory (Theory from the Old Testament; Iron Conception), any canine cancer is a subtle iron disease; a form of iron lottery. Ceramic needles can suppress any tumors and large metastases; can quickly create harmless infiltrations (harmless necroses; deposits of cells that die; benign capsules); can enter solution [sulfur (2%) + olive oil (98%); 36.6C - 39.0C] to tumors and large metastases. Anti-iron slow blood loss (even 75%) [hemoglobin control], anti-iron goat’s milk diet and anti-iron drinking water containing hydrogen sulfide can neutralize any micro-metastases and isolated cancerous cells.  http://www.medicalnewstoday.com/opinions/177680  ;  http://www.medicalnewstoday.com/opinions/177586  ;  http://www.medicalnewstoday.com/opinions/177506  ;  http://www.medicalnewstoday.com/opinions/177452  ;  http://www.medicalnewstoday.com/opinions/177370  ;  http://www.medicalnewstoday.com/opinions/177299  ;  plus.google.com/107119198688120551734/posts  ;  galacticconnection.com/.../  ;  www.facebook.com/.../658257930905936  ;  healthland.time.com/.../  ;  www.aahanet.org/.../...herapy-for-use-in-dogs.aspx  ;  Together We (American Animal Hospital Association, Medical Xpress, Medical News Today, Galactic Connection, Ovarian Cancer Facts, News-Medical.Net, TIME, Google, Facebook, YouTube, YAHOO! and Vadim Shapoval) Will Beat Cancer

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