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Alpha-2 agonists

α-2 Adrenergic receptors are located with opioid receptors. Thus, the two drug classes used together are highly synergistic for sedation and analgesia. α-2 agonists have a versatile dosing profile. That allows low and even micro-doses in combination with opioids to be clinically useful and minimizes the cardiovascular effects. Clinicians should be mindful that cardiovascular side effects occur even with very low doses of α-2 adrenergic agonists, that lower doses will have a shorter duration of effect, and that analgesic effects have a shorter duration than the sedative effects.

The information provided on this site is intended for your general knowledge only and is not a substitute for professional medical advice or treatment for specific medical conditions. You should not use this information to diagnose or treat your pet’s health problem or disease without consulting with a veterinarian. Please consult your veterinarian with any questions or concerns you may have regarding your pet’s condition.