Studies focus on lymphoma

Two new studies from two universities show promise for the identification and treatment of lymphoma in dogs, and possibly humans.

One study, from the University of California – Davis identifies a protein that appears to play a key role in the formation of lymphoma and other tumors by inhibiting a tumor-suppressing gene. The UC- Davis researchers suggest that the protein could be targeted to diagnose and ultimately treat lymphoma in humans and animals.

The research was published in the journal Genes & Development.

The other study, by the University of Pennsylvania’s School of Veterinary Medicine, showed that dogs that spontaneously develop a certain type of lymphoma (Activated B-Cell Diffuse Large B-Cell Lymphoma, or ABC-DLBCL), share a common malfunctioning intracellular pathway with humans. In addition, they found a drug that inhibits the pathway could kill the malignant lymphocytes.

The study was published in the journal Clinical Cancer Research.

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