KBroVet fully approved by FDA for control of seizures in dogs

On January 21, 2026, the FDA granted full approval to KBroVet (potassium bromide chewable tablets, Pegasus Laboratories) for the control of seizures in dogs with idiopathic epilepsy. KBroVet was conditionally approved for this indication in January 2021. This medication is a once-daily French vanilla-flavored tablet. 

The only other anticonvulsant with a label indication for idiopathic epilepsy in dogs is Fidoquel-CA1 (phenobarbital tablets, Genus Lifesciences), which was conditionally approved by the FDA in 2023.  

A history of potassium bromide for dogs 

A literature review published in JAVMA in 2012 noted references to potassium bromide use in animals as far back as 1876. The drug was originally available over-the-counter for use in humans and animals, but it is no longer used in humans in the United States. 

Potassium bromide has been used both as an adjunctive treatment alongside other anticonvulsants, such as phenobarbital, and as a stand-alone treatment option for idiopathic epilepsy.  

Before KBroVet’s conditional approval, potassium bromide was only available in compounded formulations produced by compounding pharmacies or prepared in veterinary hospitals. 

Safety information 

In their press release, the FDA cautioned that it is important for clients whose dogs take potassium bromide for idiopathic epilepsy to work closely with their veterinarians to avoid bromide intoxication, in which high levels of the drug “overwhelm the nervous system.”   Signs of bromide intoxication can include depression, behavioral changes, poor coordination, weakness or partial loss of voluntary movement in hind limbs, dilated pupils, stupor, and coma. 

According to the manufacturer prescribing information, dogs taking KBroVet should be monitored carefully when changing diets, administering chloride-containing IV fluids, and when taking other medications. Dogs who may have difficulty maintaining electrolyte balance or who have decreased renal function should be monitored especially closely, as they may be at increased risk for bromide toxicosis. 

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