The not generally recommended category of vaccines pertains to diseases of low clinical significance or that respond readily to treatment; vaccines for which evidence of efficacy in the field is minimal; or vaccines that may produce a relatively higher incidence of adverse events with limited benefit. The Task Force lists the feline infectious peritonitis (FIP) vaccine as not generally recommended. This vaccine is labeled for administration from 16 weeks of age, whereas many kittens become infected with coronaviruses well before this age. It also contains a serotype II strain of FIP virus. Serotype I FIP virus strains predominate in the field and do not have cross-reactive neutralizing epitopes with serotype II strains. Therefore, as noted in the previous iteration of these guidelines,^1,33 there remains insufficient evidence that this vaccine induces clinically relevant protection in the field.

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