Therapeutic weight loss diets are recommended for patients undergoing significant calorie restriction (less than or equal to RER) for weight loss. These diets are fortified in nutrients to avoid potential nutrient deficiencies associated with caloric restriction. High-protein diets can spare lean mass with calorie restriction during weight loss.^65,66 Protein and added fiber can promote a satiety effect.^67,68 Added fiber to a therapeutic diet will also reduce caloric density. High-moisture diets for cats may increase satiety and help promote weight loss.⁶⁹