Table 4: Antimicrobials for Skin Infections in Dogs

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Table 4: Antimicrobials for Skin Infections in Dogs1*

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First-tier empiric antimicrobials
Clindamycin 5.5–11 mg/kg PO q 12 hr
Cephalexin 22–30 mg/kg PO q 12 hr
Amoxicillin clavulanate 14–25 mg/kg PO q 12 hr
Trimethoprim-sulfadiazine/ sulfamethoxazole 15–30 mg/kg PO q 12 hr
First OR second tier
Cefpodoxime 5–10 mg/kg PO q 24 hr
Cefovecin 8 mg/kg SC q 14 days
Second tier ONLY with culture and susceptibility
Minocycline 5–10 mg/kg PO q 12 hr
Doxycycline 5–10 mg/kg PO q 12 hr
Enrofloxacin 5–20 mg/kg PO q 24 hr
Marbofloxacin 2.75–5.5 mg/kg PO q 24 hr
Pradofloxacin 3 mg/kg PO q 24 hr
Chloramphenicol 40–50 mg/kg PO q 8 hr
Rifampin 3–6 mg/kg PO q 24 hr2
Do NOT use for Staphylococcus spp. infections

PO, orally; SC, subcutaneously.

*For more information on antimicrobial stewardship, see the 2022 AAFP/AAHA Antimicrobial Stewardship Guidelines at antimicrobials.

  1. Hillier A, Lloyd DH, Weese JS, et al. Guidelines for the diagnosis and antimicrobial therapy of canine superficial bacterial folliculitis (Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases). Vet Dermatol. 2014;25:163–e43.
  2. Harbour L, Schick A, Mount R, White A. Rifampicin treatment of canine multidrug-resistant meticillin-resistant staphylococcal pyoderma: A retrospective study of 51 cases. Vet Dermatol. 2022;33(5):384–91.

The 2023 AAHA Management of Allergic Skin Diseases in Dogs and Cats Guidelines are generously supported by Hill’s Pet Nutrition, Merck Animal Health, and Zoetis.

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